Non-surgical correction of the glabella wrinkles

The glabella, i.e. the area between the eyebrows, is very significant for the aesthetics of the face. Very often negative expressions such anger, gloom or skepticism are reflected in the form of a deep wrinkle or crease in the area between the eyes.

What is the reason of appearing wrinkles in the glabella region, i.e. the area between the eyebrows?

The wrinkles, which are formed over the years between the eyebrows, are a result of chronic muscular contraction of three muscles located in the glabella region: the pyramidalis muscle (centrally) and the two corrugator supercilii muscles (one on each side).

As we grow old, the constant frowning activity of the muscles mentioned above “carves” the glabella region and usually creates one or two unsightly deep wrinkles similar to creases.

The real reason of appearing wrinkles in the glabella region is the constant muscular contraction of the three muscles, which create over the years a “hollow” in the glabella region, like there is a tissue deficit.

How can we correct the glabella wrinkles, i.e. the wrinkles between the eyebrows?

The improvement or disappearance of glabella wrinkles can be possible with the combination of two treatments: ƁOƬOX (firstly) and (then) Hyaluronic Acid.

How does the ƁOƬOX correct the wrinkles between the eyebrows and what is its mechanism of action?

ƁOƬOX (also known as botulinum toxin), when selectively applied on the procerus and the corrugator supercilii muscles, deactivates the action of these muscles, responsible for the appearance of the glabella wrinkles. This way, the muscles are not contracted and the wrinkles are getting smoother.

ƁOƬOX contributes in the glabella wrinkles getting smoother, but not totally disappearing. In such a case, one week after the ƁOƬOX we should proceed with the application of injectable Hyaluronic Acid on the glabella region in order to disappear the unsightly wrinkles by 100%.

How can we correct the glabella wrinkles using Hyaluronic Acid?

In the area of glabella wrinkles we apply a local anesthetic cream for 20-25 minutes in order to avoid pain.
We inject the implant of the Hyaluronic Acid with the help of a very fine needle into certain areas in the glabella region, respecting the anatomical features of the region.

Does the application of injectable Hyaluronic Acid hurt?

In experienced hands the treatment is completely painless, or mildly annoying. It has several technical particularities and it is extremely safe with impressive results.
The treatment takes place at the clinic. It is a painless procedure, since it is always used a local anesthetic cream or local anesthesia.

How long does this procedure take and what should we do afterwards?

The entire procedure takes 10-15 minutes and the results are immediately visible. After the treatment it is required to apply ice at the injection sites for 2 hours approximately.

Afterwards there may appear a slight skin irritation and swelling at the injection sites, which usually disappears within 24-48 hours and can be easily covered with the use of make-up.

In order to have a complete and perfectly controlled result, it is necessary to repeat this treatment twice within 7-10 days.

It is very impressive that a deep glabella wrinkle takes about 15-20 years to be formed, while it takes only 10 minutes to disappear, with only two ƁOƬOX and Hyaluronic Acid sessions.

Is the application of injectable Hyaluronic Acid in the glabella region safe?

In order to have a successful result by correcting the wrinkles or creases between the eyes, given that the glabella region has fine features and a special anatomy, it is necessary to:

  1. use injectable Hyaluronic Acid of specific density
  2. use super-fine special injection needles
  3. address to a plastic surgeon, who has a great experience and familiarity with those techniques, as well as in-depth knowledge of anatomy.

This way we can achieve a completely safe, harmonious and controlled result.

Is there any possibility of side effects because of the Hyaluronic Acid?

Since the Hyaluronic Acid molecule is almost similar to that in the human tissues, the injectable Hyaluronic Acid is highly safe.

The Hyaluronic Acid is a completely inert substance. This means that the Hyaluronic acid does not cause any:

  1. allergies
  2. side effects
  3. inflammations
  4. malignancies
  5. collagenoses


Also the Hyaluronic Acid is not displaceable, thus it remains where it has been implanted, maintaining its desirable result for a long period of time.

When the Hyaluronic Acid is properly applied into the tissues, it may cause a slight swelling at the injection sites, which can be appeared untimely. Yet, the swelling subsides easily with the use of simple anti-inflammatory medicine.
Another incident that can, scarcely, happen after the injection of Hyaluronic Acid is the appearance of small bruises on the injection sites, which automatically subside within a few days.
A very rare side effect of the Hyaluronic Acid that can occur at a rate of 2‰ cases is a mild hypersensivity reaction of the human organism, which is characterized by the appearance of swelling at the injection sites and it can treated by administrating an ANTIDOTE.

Is the Hyaluronic Acid the only one implant that has an ANTIDOTE?

The Hyaluronic Acid is the only IMPLANT of the contemporary plastic surgery that has an ANTIDOTE.

Considering that the Hyaluronic Hcid is a glycosaminoglycan, i.e a glycoprotein, there is an enzyme, which can break the Hyaluronic Acid down.

The ANTIDOTE substance is injectable and is found in liquid form, which at any time can degrade and eliminate the implant of Hyaluronic Acid scarce.

In addition to other injectable implants, the use of hyaluronic acid is ideal since we can reduce the excess quantity of Hyaluronic Acid any time injecting the antidote substance into the application sites in order to break the excess material down.

By injecting the ANTIDOTE of substance the face can be restored at 100% in its former state. The Hyaluronic Acid is broken down by the antidote substance and is removed from the human body after a few minutes or hours.

The existence of the Hyaluronic Acid ANTIDOTE makes it UNIQUE, since there is NO OTHER contemporary injectable implant of the plastic surgery with an ANTIDOTE.

The antidote substance can be used during the application procedure of Hyaluronic Acid, even if an excessive quantity of the material has been misplaced. In any case we can remove the Hyaluronic Acid from the lips in the future.

How long do the results of correcting the glabella wrinkles using both Hyaluronic Acid and ƁOƬOX last?

The duration of action of ƁOƬOX is about 3 1/2 to 4 1/2 months. However in the case of glabella we highly recommend to repeat the ƁOƬOX treatment about twice a year in order to have a perfect and stabilized result.

When it comes to the hyaluronic acid, it is well known that it is not a permanent material but it is gradually absorbed by the tissues.
Specifically the hyaluronic acid is absorbed in the glabella region at about 15% to 30% within the first year. This means that the Hyaluronic Acid, which has been injected into the nose it does not disappear after one year of its application, but remains stable at about 80%-85%. All we have to do is to refill the quantity of the Hyaluronic Acid, which has been absorbed, in order to maintain a successful result.